What are the biggest challenges when trying to publish scientific paper in high-impact journals?

Publishing research in top-tier journals often feels like an uphill climb. Between strict submission guidelines, reviewer expectations, and the pressure to present original findings, it’s easy to feel lost in the process. For early-career researchers especially, figuring out what makes a paper stand out can be confusing. I’m curious how others approach this — what steps or strategies have helped you successfully publish scientific paper in high-impact journals without losing motivation or confidence along the way?